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Cognitive & Neuroprotective Peptide

SEMAX

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CAS: 129954-34-3SelancThr-Lys-Pro-Arg-Pro-Gly-Pro

A 7-amino acid synthetic heptapeptide analog of ACTH (4–10) that enhances BDNF expression and modulates TrkB signaling pathways, investigated for cognitive support and neuroprotective effects in clinical research. Premium Research Peptide.

Original price was: $64.99.Current price is: $58.49.

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How SEMAX Works

The Science, Simplified

Neurotrophic Factor Upregulation

Semax is a synthetic heptapeptide analog of a fragment of ACTH (adrenocorticotropic hormone). Its primary mechanism in research is the rapid elevation of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF).
Key insight: By boosting these “brain fertilizers,” Semax supports the survival and growth of neurons. In laboratory models, this has been shown to enhance synaptic plasticity, which is the foundational process for long-term memory formation and learning
GE
Primary

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

COL
Strongest

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Cu²⁺
Supportive

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Selective Neurotransmitter Modulation

Unlike stimulant-based nootropics, Semax subtly modulates the dopaminergic and serotonergic systems without leading to receptor depletion or "crashing."

Key insight: Research suggests it enhances dopaminergic signaling, which improves motivation and executive function. It also activates the serotonergic system, supporting emotional stability and mood regulation during high-stress cognitive tasks.

Transcriptome & Ischemic Protection

Semax has a profound effect on gene expression, specifically suppressing genes related to inflammation while activating genes involved in neurotransmission.

Key insight: This “transcriptome compensation” makes it a primary subject for stroke and traumatic brain injury (TBI) research. In ischemic models, Semax administration is observed to reduce infarct size and accelerate the recovery of motor and cognitive functions.

Wrinkle Reduction Comparison

Safety Profile from Research

What clinical studies report

Semax has been used in clinical practice in Eastern Europe since the 1990s and maintains a robust safety record in both human and animal studies.

🧿 Common Digestive Issues

10%

Nasal Irritation

mild

8%

Restlessness

mild

5%

Mild Headache

mild

Safety Advantage

Non-Hormonal Design

  • No Adrenal Impact: Although derived from ACTH, Semax is engineered to lack hormonal activity. It does not stimulate the adrenal glands or affect cortisol levels, avoiding the side effects of native ACTH
  • Non-Addictive: Clinical research indicates no potential for addiction, physical dependence, or withdrawal symptoms.
  • Rapid Elimination: With a plasma half-life of 1-2 hours, it is metabolized into natural amino acids, preventing long-term accumulation in the body.

📊 Discontinuation Rates

🚫 Trial Exclusions

⚡ Regulatory Status

💡 Researcher Notes

Compound Information

Technical specifications for each component

🔬 Molecular Profile

What Is Semax?

Type

Synthetic heptapeptide

CAS Number

80714-61-0

Molecular Formula

C37H51N9O10S

Molecular Weight

813.9 g/mol

Amino Acids

7 residues

Sequence

Met-Glu-His-Phe-Pro-Gly-Pro

PubChem Database

🧊 Storage Requirements

Stability Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

Lyophilized (powder)

-20°C

protect from light

Reconstituted

2-8°C

use within 4 weeks

Nasal spray

2-8°C

30 days after opening

📋 Development Status

Regulatory Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

Developer

Russian Academy of Sciences

Approval

Russia (1990s)

Indications

Stroke, cognitive impairment

Formulations

0.1% and 1% nasal spray

US Status

Not FDA-approved

Related Peptide

Selank (tuftsin analog)

Wikipedia

Frequently Asked Questions

Common questions about SEMAX

No. While it improves focus and attention, it does not work like caffeine or amphetamines. Instead of forcing a release of adrenaline, it optimizes the brain's internal signaling and blood flow, providing "calm clarity" rather than jittery energy.
NA-Semax (N-Acetyl Semax) is a modified version with an acetyl group added to the start of the peptide chain. In research, this modification is studied for its ability to increase the peptide's stability and its ability to cross the blood-brain barrier even more effectively than the original.
Semax is unique because it works on several levels: it reduces inflammation, protects cells from oxygen deprivation (hypoxia), and increases the production of growth factors. This multi-pathway approach is critical for protecting brain tissue during an ischemic event.
Intranasal administration allows Semax to bypass the blood-brain barrier rapidly. In research settings, cognitive effects are often observed within 30-60 minutes, though neuroprotective benefits related to gene expression may take several days of consistent administration to reach peak efficacy.
No. It is a prescription medication in some Eastern European countries but is classified as an investigational research compound in the United States. It is sold strictly for laboratory research and is not intended for human consumption.

Sources & References

Peer-reviewed research

Brain Research

Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus

2006

Dolotov OV, Karpenko EA, Inozemtseva LS, et al.

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BMC Genomics

The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia

2014

Medvedeva EV, Dmitrieva VG, Povarova OV, et al.

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Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

The efficacy of semax in the treatment of patients at different stages of ischemic stroke

2018

View Source

Journal of Molecular Neuroscience

Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action

2010

Shadrina M, Kolomin T, Agapova T, et al.

View Source

International Journal of Molecular Sciences

Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Molecular Level

2020

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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