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Cognitive & Anxiolytic Peptide

SELANK

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CAS: 129954-34-3SelancThr-Lys-Pro-Arg-Pro-Gly-Pro

A 7-amino acid synthetic heptapeptide derived from tuftsin that modulates GABAergic neurotransmission and BDNF expression, studied for anxiolytic and nootropic effects in clinical research. Premium Research Peptide.

Original price was: $64.99.Current price is: $58.49.

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How SELANK Works

The Science, Simplified

The Master Coenzyme for Energy

Selank is a synthetic heptapeptide derived from tuftsin, a natural immunomodulatory peptide. It modulates the GABAergic system through allosteric regulation of GABA-A receptors, reducing anxiety without the “heaviness” of traditional medications.
Key insight: Unlike benzodiazepines, clinical research shows that Selank reduces anxiety without causing sedation, memory impairment, or physical dependence. This allows researchers to study anxiety reduction while the subject maintains full cognitive clarity.
GE
Primary

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

COL
Strongest

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Cu²⁺
Supportive

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Nootropic & BDNF Upregulation

Selank is observed to increase the expression of Brain-Derived Neurotrophic Factor (BDNF), a protein critical for the survival of existing neurons and the growth of new ones.

Key insight: This mechanism supports synaptic plasticity, memory consolidation, and learning. In research, Selank is often classified as a “nootropic anxiolytic” because it facilitates mental focus and attention rather than dulling it.

Enkephalin Protection

Selank inhibits the enzymes that break down enkephalins, which are the body's natural "stress-relief" opioids.

Key insight: By prolonging the activity of enkephalins, Selank helps modulate the emotional response to stress. This dual action—protecting natural calming signals while optimizing neurotransmitter levels—makes it a cornerstone of adaptive stress-regulation studies.

Wrinkle Reduction Comparison

Safety Profile from Research

What clinical studies report

Selank is exceptionally well-tolerated, largely because it breaks down into natural amino acids that the body already recognizes and utilizes.

🧿 Common Digestive Issues

10%

Nasal Irritation

mild

8%

Mild Headache

mild

5%

Vivid Dreams

mild

Safety Advantage

No Dependence

  • Zero Sedation: Clinical trials consistently report an absence of drowsiness or muscle relaxation, distinguishing it from pharmaceutical tranquilizers.
  • No Withdrawal: Unlike benzodiazepines, there is no evidence of tolerance development or withdrawal symptoms upon cessation of a research protocol.
  • Cognitive Preservation: Research shows no negative impact on amnesia or mental motor skills, making it safe for studies requiring complex task performance.

📊 Discontinuation Rates

🚫 Trial Exclusions

⚡ Regulatory Status

💡 Researcher Notes

Compound Information

Technical specifications for each component

🔬 Molecular Profile

What Is Selank?

Type

Synthetic heptapeptide

CAS Number

129954-34-3

Molecular Formula

C33H57N11O9

Molecular Weight

751.9 g/mol

Amino Acids

7 residues

Sequence

Thr-Lys-Pro-Arg-Pro-Gly-Pro

PubChem Database

🧊 Storage Requirements

Stability Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

Lyophilized (powder)

-20°C

protect from light

Reconstituted

2-8°C

use within 4 weeks

Nasal spray (0.15%)

2-8°C

30 days after opening

📋 Development Status

Regulatory Information

Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences

Developer

Russian Academy of Sciences

Collaborator

V.V. Zakusov Institute

Approval

Russia (2009), Ukraine

Indication

Generalized Anxiety Disorder

US Status

Not FDA-approved

Formulation

0.15% nasal drops (Rx in Russia)

Frequently Asked Questions

Common questions about SELANK

While all three target the GABA system, Selank does not directly bind to the benzodiazepine site. Instead, it "adjusts" how the receptor responds. This results in similar anxiety relief (~85% effectiveness in GAD trials) but without the risk of addiction, sedation, or the "brain fog" associated with Phenibut or pharmaceutical tranquilizers.
Selank has a high intranasal bioavailability (~92.8%). Because it is a small peptide, it can bypass the blood-brain barrier effectively when administered intranasally, allowing for direct action on the central nervous system within minutes.
Yes. Because it optimizes dopamine and serotonin levels while boosting BDNF, researchers often use Selank to study improvements in attention span, learning speed, and "mental stamina" during periods of high cognitive demand.
Tuftsin is a natural part of our immune system. Selank was created by adding three amino acids to the tuftsin structure to make it more stable. This means that in addition to brain health, Selank is also researched for its ability to balance the immune response (immunomodulation).
No. While it has been prescribed in Russia since 2009 for Generalized Anxiety Disorder (GAD), it is currently classified in the US as an investigational research compound. It is not intended for human use and is sold strictly for laboratory scientific research.

Sources & References

Peer-reviewed research

Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia

2008

Zozulia AA, Neznamov GG, Siuniakov TS, et al.

View Source

Behavioural Neurology

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

2017

Kasian A, Kolomin T, Andreeva L, et al.

View Source

Frontiers in Pharmacology

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

2016

Volkova A, Shadrina M, Kolomin T, et al.

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Bulletin of Experimental Biology and Medicine

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

2019

Kozlovskii II, Andreeva LA, Myasoedov NF

View Source

Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova

A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders

2014

Medvedev VE, Tereshchenko ON, Israelian AIu, et al.

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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