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Cellular Peptide

NAD+

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Beta-NADCoenzyme INicotinamide Adenine Dinucleotide

A vital dinucleotide coenzyme that activates sirtuins and supports mitochondrial function, investigated for its role in cellular energy metabolism in research models.

Original price was: $64.99.Current price is: $58.49.

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How NAD+ Works

The Science, Simplified

The Master Coenzyme for Energy

NAD+ is a critical dinucleotide coenzyme found in every living cell. It serves as an essential electron carrier in the mitochondrial electron transport chain, which is responsible for generating ATP (cellular energy).
Key insight: Research indicates that as NAD+ levels decline with age, mitochondria enter a “pseudohypoxic” state. Supplementing NAD+ in research models helps restore mitochondrial-nuclear communication, effectively “recharging” the cellular powerhouses.
GE
Primary

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

COL
Strongest

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Cu²⁺
Supportive

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Sirtuin & "Longevity Gene" Activation

NAD+ is the mandatory substrate for Sirtuins (SIRT1-7), a family of enzymes that regulate aging, DNA repair, and inflammation.

Key insight: Without sufficient NAD+, sirtuins remain inactive. By providing this coenzyme, researchers can observe enhanced genomic stability and a reduction in age-related cellular dysfunction, as sirtuins use NAD+ to “switch on” protective pathways.

DNA Repair & PARP Enzymes

NAD+ fuels PARPs (poly-ADP-ribose polymerases), which are enzymes tasked with detecting and repairing damaged DNA.

Key insight: Constant DNA repair is a high-energy process that consumes significant amounts of NAD+. Maintaining high levels of this coenzyme in research ensures that these repair mechanisms have the “fuel” needed to maintain genomic integrity against environmental stressors.

Wrinkle Reduction Comparison

Safety Profile from Research

What clinical studies report

NAD+ is an endogenous molecule, meaning it is naturally produced by the body, which contributes to its generally high safety profile in research.

🧿 Common Digestive Issues

35%

Flushing/Warmth

mild

40%

Mild Nausea

mild

25%

Chest Tightness

mild

Safety Advantage

Endogenous Recognition

  • Natural Molecule: Because the body already utilizes NAD+ for hundreds of reactions, it is typically well-tolerated without the risk of immune-mediated rejection.
  • Non-Toxic: Clinical studies involving over 1,500 participants have found no significant organ toxicity or serious adverse events at standard research concentrations.
  • Rate-Dependent: Most reported side effects in research are not caused by the compound itself, but by the speed at which it is introduced to the system, allowing for easy management by adjusting administration rates.

📊 Discontinuation Rates

🚫 Trial Exclusions

⚡ Regulatory Status

💡 Researcher Notes

Compound Information

Technical specifications for each component

🔬 Molecular Profile

NAD+ Structure

CAS Number

53-84-9

Molecular Formula

C21H27N7O14P2

Molecular Weight

663.43 g/mol

Type

Dinucleotide coenzyme

Components

Nicotinamide + Adenine + Ribose + Phosphate

Cell Metabolism 2015

🧊 Storage Requirements

Stability Information

Stability and storage requirements

Powder Form

Store at -20°C

and protect from light.

Liquid Form

Use promptly;

unstable at room temperature.

Shelf Life

24 months

if kept frozen and sealed.

📊 Physical Properties

Handling & Storage

Stability and storage requirements

Appearance

White to off-white powder

Solubility

Freely soluble in water

Storage (powder)

-20°C, protected from light

Solution stability

Use promptly, refrigerate

Frequently Asked Questions

Common questions about NAD+

Age is the primary factor—by age 50, most people have roughly half the NAD+ they had in their youth. However, chronic inflammation, high oxidative stress, and DNA damage also act as "NAD+ sinks," consuming the coenzyme faster than the body can replenish it.
NMN and NR are "precursors"—they are the building blocks the body uses to create NAD+. In research, using pure NAD+ allows for a more direct observation of the coenzyme’s effects without relying on the subject's internal conversion enzymes, which may be compromised by age.
Because it powers sirtuins. Sirtuins are known as the "guardians of the genome" because they control how our genes are expressed and repaired. Since sirtuins cannot function without NAD+, this coenzyme is seen as the master key to unlocking age-reversing biological processes.
This is a major area of current research. While larger molecules often struggle to enter the brain, some studies suggest that NAD+ or its metabolites can influence neuro-inflammation and cognitive function, possibly through secondary signaling pathways.
No. NAD+ is currently classified as a nutraceutical or investigational research compound depending on its form. It is not approved for the treatment or prevention of any disease and is sold strictly for laboratory evaluation.

Sources & References

Peer-reviewed research

Frontiers in Endocrinology

Association of Human Whole Blood NAD+ Contents With Aging

2022

Yang F, et al.

View Source

Trends in Cell Biology

NAD+ and Sirtuins in Aging and Disease

2014

Imai S, Guarente L

View Source

Antioxidants

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+

2019

Grant R, et al.

View Source

Circulation

NAD+ Metabolism in Cardiac Health, Aging, and Disease

2021

Abdellatif M, et al.

View Source

Nature Metabolism

NAD+ Homeostasis in Health and Disease

2020

Katsyuba E, et al.

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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