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GHRH Secretagogue

CJC

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CJC/Ipa Blend

A synthetic growth hormone–releasing hormone (GHRH) analog that stimulates natural GH secretion, studied for its effects on hormone regulation and pulsatile release patterns in research models. Premium Research Peptide.

Original price was: $64.99.Current price is: $58.49.

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Third Party Tested by Freedom Diagnostics

How CJC Works

The Science, Simplified

Sustained GHRH Receptor Agonism

CJC-1295 is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH) that stimulates the body’s natural growth hormone system.
Key insight: It binds to GHRH receptors in the pituitary gland, triggering endogenous growth hormone release and increasing downstream IGF-1 production without replacing natural GH directly.
GE
Primary

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

COL
Strongest

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Cu²⁺
Supportive

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

DAC vs Non-DAC Functional Behavior

CJC-1295 exists in two research forms with different duration profiles.

Key insight: With DAC, the peptide binds to albumin in the bloodstream, extending its half-life to ~6–8 days and producing sustained GH elevation. Without DAC (Mod GRF 1-29), it clears rapidly and produces short, natural GH pulses closer to physiological release patterns.

GH–IGF-1 Axis Regulation

CJC-1295 is primarily used in research for its ability to enhance the GH–IGF-1 axis.

Key insight: Studies show GH levels can increase 2–10x from baseline after administration, while IGF-1 may remain elevated for extended periods depending on dosing frequency, supporting anabolic and metabolic signaling.

Wrinkle Reduction Comparison

Safety Profile from Research

What clinical studies report

CJC-1295 with DAC has been studied in Phase II clinical trials. While generally well-tolerated, its long-acting nature requires careful monitoring in research protocols.

🧿 Common Digestive Issues

25%

Injection Site Flushing

mild

15%

Water Retention

mild

10%

Lethargy

mild

Safety Advantage

High Selectivity

📊 Discontinuation Rates

🚫 Trial Exclusions

⚡ Regulatory Status

💡 Researcher Notes

Compound Information

Technical specifications for this long-acting GHRH analog

🔬 Molecular Profile

What Is CJC?

Category

Growth hormone secretagogue

Type

GHRH analog (long-acting or short-acting variant)

CJC-1295 with DAC

Half-life ~6–8 days

CJC-1295 (No DAC / Mod GRF 1-29):

Half-life ~30 minutes

Molecular Weight

~3367.9 Da

CAS Number

863288-34-0

Sequence

Modified GHRH (1-29) + DAC

Purity

≥99%

🧊 Storage Requirements

Stability Information

Lyophilized (powder)

Store at -20°C

(Stable for 24 months).

Reconstituted

Store at 2-8°C;

use within 14-21 days.

Light Sensitive

Store in a dark environment

to prevent degradation.

📋 Blend Information

Development History

Classification

GHRH analog / growth hormone secretagogue

Primary focus

GH release and IGF-1 elevation research

Evidence base

Early clinical trials, mechanistic studies, and small-scale research

Clinical limitation

Limited large-scale randomized controlled trials

Regulatory status

Investigational research compound (not FDA-approved)

Frequently Asked Questions

Common questions about CJC

The main difference is the frequency of administration. CJC-1295 No DAC (also known as Mod GRF 1-29) has a half-life of about 30 minutes and requires multiple daily doses. CJC-1295 with DAC has a half-life of 8 days, meaning it only needs to be administered once or twice a week in a research setting to maintain high GH levels.
While it can be studied alone, many researchers pair it with a GHRP like Ipamorelin. CJC-1295 acts as the "gas pedal" for GH production, while Ipamorelin acts as the "trigger" for the release. Together, they create a synergistic effect that significantly amplifies GH output.
DAC stands for Drug Affinity Complex. It is a chemical tail (Nɛ-maleimidopropionyl-Lysine) that allows the peptide to hitch a ride on albumin, a common protein in your blood. This prevents the kidneys from filtering it out quickly, which is why it stays active for so long.
Yes, this is a term used in research to describe the constant, elevated background level of Growth Hormone. While this is highly effective for fat loss and muscle repair, some researchers prefer the "No DAC" version because it more closely mimics the natural "up and down" spikes of the human body.
No. It reached Phase II clinical trials for growth hormone deficiency but is currently classified as an investigational research compound. It is not approved for human use or as a medical treatment.

Sources & References

Peer-reviewed research

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.